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Objective To investigate the curative effect of glucocorticoid and hyperbaric oxygen therapy on the high-frequency and diminishing sudden deafness.Methods A total of 260 patients with high-frequency and diminishing sudden deafness were divided into hormone group(n=110),hyperbaric oxygen group(n=80) and routing group(n=70,ginaton 87.5 mg+5% GS 250 mL static drops static drops,intramuscular injection of vitamin B1 1.5 mg+cobamamide 0.1 g and 2% lidocaine 10 mL+5% GS 250 mL static drops).The first two groups were added oral prednison and hyperbaric oxygen therapy on the basis of therapy of routing group.The effect of comparison analysis was conducted after 10 days of treatment according to the course of disease which was less than that of or equal to 7 days or greater than 7 days.Results The overall curative effect of hormone group and hyperbaric oxygen group was better than that of routing group,and the difference was statistically significant (P<0.05).During the whole course of disease,the difference of therapeutic effect between routing group and the other two groups was statistically significant(P<0.05).Conclusion The glucocorticoid and hyperbaric oxygen therapy both have really curative effect on high-frequency and diminishing sudden deafness.
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Objective To discuss peer education on the rehabilitation in schizophrenia recovery.Methods According to the order of admission,108 cases of hospitalized recovery of schizophrenia patients were divided into observation group and control group,each group in 54cases.The observation group received psychiatric conventional treatment and care at the same time add peer educations,the control group only accepted psychiatric conventional treatment and care.The observation group was given for a period of 20 weeks peer education.The nurse brief mental scale (N -BPRS),self -knowledge and treatment attitude questionnaire scale (ITAQ)were assessed in the two groups at the beginning,10 weeks,20 weeks.Results The difference of N -BPRS score between the two groups was not statistically significant (t =0.191,P =0.850).In the observation group,the scores had significant differences between 10 weeks and 20 weeks peer education (t =2.757,P =0.069;t =4.000,P =0.000).The ITAQ scores of the observation group at the beginning,20 weeks peer education were (11.22 ±3.55)points,(17.22 ±4.31)points, the difference was statistically significant (P 0.05).Conclusion Schizophrenia convalescence patients accept peer education is helpful to rehabilitation.
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Objective To discuss the differences of clinical features and characteristics and features of polysomnography be‐tween elderly patients and middle‐aged patients with obstructive sleep apnea hypopnea syndrome (OSAHS) ,so as to provide refer‐ence for the diagnosis and individualized intervention of elderly OSAHS .Methods Totally 81 aged OSAHS cases and 123 youth OSAHS cases were analyzed in terms of general condition ,clinical manifestations and polysomnographic characteristics ,and the clin‐ical manifestations and polysomnographic difference indicators of the two groups were matched according to body mass index (BMI) .Results Most OSAHS patients were males in both groups ,with BMI and neck waist circumference in the aged group less than those in the middle‐aged group ,and the difference was statistically significant (P0 .05);clinical symptoms of senile groups such as drowsiness ,snoring ,morning headaches ,dry mouth and nighttime awakenings were lower than the middle‐aged group ,the difference was statistically significant (P0 .05);REM AHI was more than the middle‐aged group ,the difference was statistically significant (P0 .05) .Conclusion The incidence of typical clinical manifestations of aged OSAHS patients was lower than that in the middle‐aged group ,but high blood pressure ,diabetes and other complications prevalence were significantly higher than those in the middle‐aged group ,with similar severity of OSAHS in both groups ,there were differences PSG monitoring results with the middle‐aged group ,and the difference of REM AHI was significant .
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Objective To observe the therapeutic efficacy of different treatment programs on the acute subjective tinnitus . Methods 327 patients with acute subjectivity tinnitus were randomly divide into physical ,medication and comprehensive treatment group .The 97 cases in physical group were treated with hyperbaric oxygen ,acupuncture and sound therapy ;the 103 cases in medica‐tion group were treated with microcirculation and oral steroids ;the 127 cases in comprehensive treatment groups were treated with combination the therapy of above what have mentioned .THI was used to evaluate three groups before the treatment ,two and four weeks after treatment .Results After two week′s treatment ,the efficiency rate for physical group is 60 .82% ,64 .78% in medica‐tion group and 70 .08% in comprehensive group .After four weeks of treatment ,the efficiency rate of each group is 70 .10% , 72 .81% and 80 .31% .At two‐week time point ,there was no significant difference between drug and physics group (P> 0 .05) , there was statistically significant difference between medication group and comprehensive group (P0 .05) ,but there was a statistically significant difference in comprehensive group (P<0 .05) ,meanwhile ,there was statistically significant differences between comprehensive group and the physical group and drug group (P<0 .05) .Conclusion Physical and medication therapy have quite effects on acute subjective tinnitus ,but the effect was worse than the comprehensive therapy group . After four weeks of treatment ,the efficiency of purely physical and drug therapy have not been significantly improved compared with two weeks time ,but still improved of comprehensive treatment .
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OBJECTIVE@#To observe 18β-glycyrrhetinic acid (GA) impact on ultrastructure of tight junctions (TJs) of nasal mucosa epithelial cells in rats models of allergic rhinitis (AR).@*METHOD@#Ninety-six Wistar rats were randomly divided into control group, model group, loratadine group, and 18β-glycyrrhetinic acid group, and each group had 24 rats. Ovalbumin was used to establish a rat AR model. The behavioral changes and the tight junctions of nasal epithelial were observed and compared in different groups after 2,4,6 and 10 weeks intervention.@*RESULT@#The length of TJs in allergic rhinitis model became shorter, electron-high-density plasma membrane became thicker, number of the integration loci reduced and gap of TJs widened or even ruptured. With the consistent effect of allergens,the changes of TJs in the model group aggravated gradually,and the changes of ultrastructure of TJs in 18β-glycyrrhetinic acid group was relieved apparently compared to model group and even were close to the control model with time.@*CONCLUSION@#18β-glycyrrhetinic acid can recover the ultrastructure of the tight junctions of AR rat nasal epithelial cells.
Subject(s)
Animals , Rats , Cell Count , Epithelial Cells , Glycyrrhetinic Acid , Pharmacology , Nasal Mucosa , Cell Biology , Ovalbumin , Rats, Wistar , Rhinitis, Allergic , Drug Therapy , Tight JunctionsABSTRACT
OBJECTIVE@#To investigate the correlation of preoperative anxiety and postoperative pain after endoscopic sinus surgery in chronic rhinosinusitis (CRS) with or without nasal polyps (CRSwNP or CRSsNP).@*METHOD@#Subjects were 167 adults scheduled for functional endoscopic sinus surgery(FESS),in our hospital. preoperative issuing State-Trait Anxiety Inventory(STAI), carried anxiety scores. 8 h, 32 h, 56 h after surgery, recorded the pain score of Wong-Banker facial scale method (FPS-R). Analysed the correlation between preoperative anxiety score and the degree of postoperative pain.@*RESULT@#Patients'preoperative S-AI mean score was 42. 45 ± 9. 98, T-AI mean score was 41. 81±8. 47. The mean pain score in patients 8 h after surgery was 6. 33±1. 74,32 h was 4.21±1.51, 56 h was 2.35±1.42. In the 8 h group postoperative pain were 0 cases with no pain, 10 cases of mild pain, moderate pain in 107 cases, 47 cases of severe pain, sharp pain in three cases. After 32 hours 9 cases with no pain, 97 cases of mild pain, moderate pain in 32 cases, 29 cases of severe pain, no sharp pain patients. 56 hours after surgery, there were 108 cases with no pain, mild pain in 44 cases, 15 cases of moderate pain. Preoperative S-AI and T-AI score and 8 h, 32 h, 56 h after surgery pain score had no significant correlation.@*CONCLUSION@#The pain of patients within 8 h after FESS is most evident,with the passage of time, the degree of pain gradually reduced. Preoperative anxiety and postoperative pain have no significant correlation.